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Expression of Apoptosis Related and Proliferative Proteins in Malignant Lympho-Proliferative Disorders

Zeeba S Jairajpuri1, Rekha Ghai2, Sumita Saluja3

  • 1Dept. of Pathology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.

Iranian Journal of Pathology
|March 14, 2018
PubMed

Insights

This study analyzed apoptotic and cell proliferative proteins in lymphomas. A higher Bcl-2/Bax ratio indicates indolent lymphomas, while P53 and PCNA levels correlate with aggressive Non-Hodgkin Lymphoma grades.

Area of Science:

  • Hematopathology
  • Oncology
  • Molecular Biology

Background:

  • Lymphomas and lymphoproliferative disorders exhibit diverse histological grades and immune phenotypes.
  • Understanding the expression patterns of apoptotic and cell proliferative proteins is crucial for characterizing these conditions.

Purpose of the Study:

  • To conduct an immunohistochemical analysis of apoptotic and cell proliferative protein expression in various lymphoma subtypes and grades.
  • To correlate protein expression patterns with the biological behavior and prognostic indicators of lymphomas.

Main Methods:

  • Analysis of 60 lymph node biopsies from patients with lymphoproliferative disorders using histological and immunohistochemical techniques.
  • Quantification of Bax and BCL-2 protein expression and calculation of the Bcl-2/Bax Protein Ratio (BBPR).
  • Assessment of P53 and PCNA expression in Non-Hodgkin Lymphomas (NHL).

Main Results:

  • The mean BBPR was significantly higher in indolent lymphomas (2.64 ± 1.3) compared to aggressive lymphomas (0.47 ± 0.9).
  • P53 and PCNA expression increased progressively from low-grade to high-grade NHL.
  • The majority of biopsies (81.6%) were malignant, with B-cell lymphomas being the most common type (66%).

Conclusions:

  • The BBPR is a significant indicator correlating with the biological behavior of indolent and aggressive lymphomas, highlighting the roles of Bcl-2 and Bax.
  • Elevated P53 and PCNA expression in NHL suggests their prognostic value for tumor grading.
Abstract

Keywords:
ApoptosisBaxBcl2Malignant lymphoproliferative

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