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Lateral Flow Assay for Interleukin 6: A Technological and Scientific Prospection of a 10-Year Survey
Ingridi de Souza Sene1,2, Vladimir Costa2, Gisele Elias Nunes Pauli3
1Universidade Federal do Piaui, Teresina-PI, Brazil.
Insights
Developing a Lateral Flow Assay (LFA) for Interleukin-6 (IL-6) detection is innovative, with no existing patents found. This biosensor development holds significant biotechnological and economic potential.
Area of Science:
- Biotechnology
- Immunotechnology
- Biosensor Development
Background:
- Interleukin-6 (IL-6) is a key cytokine implicated in immune responses, cancer, and inflammatory diseases.
- Quantifying IL-6 is crucial for disease diagnosis and monitoring.
- Lateral Flow Assays (LFAs) offer a promising platform for IL-6 detection.
Purpose of the Study:
- To conduct a comprehensive technological and scientific exploration of developing a Lateral Flow Assay (LFA) for Interleukin-6 (IL-6) detection.
- To assess the novelty and innovation landscape surrounding IL-6 LFAs.
Main Methods:
- Technological prospection involved patent searches using INPI, Espacenet, and USPTO databases.
- Scientific investigation utilized Web of Science, Science Direct, PubMed, and Scielo databases from 2007 to May 2017.
Main Results:
- No patents were identified for IL-6 LFAs, indicating a gap in existing intellectual property.
- A limited number of scientific articles on IL-6 LFAs were found, highlighting the novelty of this field.
- The development of an IL-6 LFA presents significant innovation and biotechnological importance.
Conclusions:
- The development of lateral flow immunosensors for IL-6 is considered innovative due to the absence of relevant patents.
- While existing research shows promise, current IL-6 detection methods may require external equipment.
- Future developments aim to create a complete, potentially equipment-free, IL-6 detection system.
Background:
Interleukin-6 (IL-6) is a multifunctional cytokine that plays a crucial role not only in the immune system but also in numerous biological processes. Elevated IL-6 levels have been observed in many types of cancer and inflammatory diseases. Among the techniques that have been used to quantify IL-6, a Lateral Flow Assay (LFA) is one of the most promising.
Objective:
The objective of this study was to perform a technological and scientific exploration of the development of an LFA for IL-6.
Method:
The Instituto Nacional de Propriedade Industrial-INPI (Brazil), European Patent Office - Espacenet, and United States Patent and Trademark Office-USPTO were used for the technological prospection to consider all the patents regarding an LFA for IL-6 detection. For the scientific investigation, the following periodic databases were used: Web of Science, Science Direct, PubMed, and Scielo, and were monitored from 2007 to May 2017.
Results:
We found no patents based on the searched keywords, and a limited number of scientific articles were found. Therefore, the development of an LFA sensor for the detection of IL-6 appears to be innovative with significant biotechnological importance, creating a technology transfer to promote economic and industrial growth.
Conclusion:
The development of lateral flow immunosensors for IL-6 is innovative, as we could not find patents describing such a biosensor. Scientific prospection reported two lateral flow immunosensors. However, the test for IL-6 cannot be completed without using some kind of equipment for detection, such as the one we propose in future developments.
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