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Identification of Cytological Features Distinguishing Mucosa-Associated Lymphoid Tissue Lymphoma from Reactive

Ayana Suzuki1, Mitsuyoshi Hirokawa2, Aki Ito1

  • 1Department of Clinical Laboratory, Kuma Hospital, Kobe, Japan.

Acta Cytologica
|March 30, 2018
PubMed

Insights

Thyroid liquid-based cytology (LBC) can distinguish mucosa-associated lymphoid tissue lymphoma (MALT-L) from nonneoplastic lymphocytes. Large, swollen naked, and elongated nuclei are key cytological differences in LBC specimens.

Area of Science:

  • Cytopathology
  • Hematopathology
  • Thyroid Pathology

Background:

  • Distinguishing thyroid lymphoma from nonneoplastic lymphocytes is crucial for accurate diagnosis.
  • Liquid-based cytology (LBC) offers potential advantages for thyroid fine-needle aspiration analysis.

Purpose of the Study:

  • To identify distinct cytological features of mucosa-associated lymphoid tissue lymphoma (MALT-L) in thyroid LBC specimens.
  • To compare these features with nonneoplastic lymphocytes and conventional cytology.

Main Methods:

  • Analysis of LBC and conventional cytology specimens from MALT-L, diffuse large B-cell lymphoma (DLBCL), and nonneoplastic lymphocytic infiltration cases.
  • Comparative assessment of nuclear morphology, including size, shape, and chromatin patterns.

Main Results:

  • Lymphoglandular bodies were less frequent in MALT-L LBC specimens compared to conventional ones.
  • Large, swollen naked nuclei with less punctate chromatin and thin margins were significantly more prevalent in thyroid lymphoma (MALT-L and DLBCL) LBC specimens.
  • Elongated nuclei were a prominent feature distinguishing thyroid lymphoma from nonneoplastic lymphocytes in LBC.

Conclusions:

  • Lymphoglandular bodies are unreliable diagnostic markers in thyroid LBC for lymphoma.
  • Specific nuclear morphologies, including large, swollen naked, and elongated nuclei, are valuable indicators for differentiating thyroid lymphoma from nonneoplastic lymphocytes in LBC specimens.
Abstract

Keywords:
Hashimoto thyroiditisLiquid-based cytologyLymphomaMucosa-associated lymphoid tissueThyroid

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