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Published on: January 9, 2015
Introducing Transthyretin as a Differentially Expressed Protein in Washing Subtype of Obsessive-Compulsive Disorder
Mona Zamanian Azodi1, Mostafa Rezaei Tavirani1, Afsaneh Arefi Oskouie1
1Proteomics Research Center, School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Insights
Proteomic analysis reveals transthyretin (TTR) levels are altered in Obsessive-Compulsive Disorder (OCD). TTR may serve as a potential biomarker for OCD, with expression normalizing after fluoxetine treatment.
Area of Science:
- Neuroproteomics
- Biomarker Discovery
- Mental Health Research
Background:
- Obsessive-Compulsive Disorder (OCD) is a significant mental health condition.
- Understanding OCD's underlying biological mechanisms requires proteomic research.
Purpose of the Study:
- To investigate proteome profiles in female OCD patients.
- To identify potential protein biomarkers for OCD.
Main Methods:
- Gel-based proteomics was employed.
- 16 female OCD patients (washing subtype) and 20 healthy controls were analyzed.
- Samples were collected before and after fluoxetine treatment.
Main Results:
- Transthyretin (TTR) showed significant expression changes (fold change=1.7, P<0.05).
- TTR levels were decreased in untreated OCD patients.
- Fluoxetine treatment partially normalized TTR expression in responders.
Conclusions:
- Transthyretin (TTR) is a potential biomarker for OCD.
- Further validation studies for TTR as an OCD biomarker are warranted.
Introduction:
Obsessive-Compulsive Disorder (OCD) as one of the important mental problems is valuable topic for proteomic research studies to better understand the underlying mechanisms of this disorder.
Methods:
In this paper, gel-based proteomic was used to investigate the proteome profile of 16 female patients with OCD, washing subtype before and after treatment with fluoxetine and comparing them with 20 healthy female controls.
Results:
One of the abnormally expressed protein spots in this study was introduced and examined for protein-protein interaction network analysis via Cytoscape and its plug-ins. Transthyretin (TTR) protein showed significant expression changes (fold change=1.7, P<0.05). While the expression level of TTR is significantly decreased in OCD patients before any treatments, the trend is partially normalized after treatment with fluoxetine in positive responders. Furthermore, TTR interaction profile shows that the proteins interacting with this protein may get affected as this protein expression trend changes in OCD patients.
Conclusion:
TTR can be considered for further studies to be validated as a potential biomarker for OCD.
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