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Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation

Maira da Costa Cacemiro1, Juçara Gastaldi Cominal1, Raquel Tognon2

  • 1Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (FCFRP-USP), Ribeirão Preto, SP, Brazil.

Hematology, Transfusion and Cell Therapy
|July 31, 2018
PubMed

Insights

Increased proinflammatory cytokines are linked to myeloproliferative neoplasms (MPNs). Specific cytokine patterns and JAK2 V617F mutation correlations were observed in essential thrombocythemia, primary myelofibrosis, and polycythemia vera.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Cytokines are crucial immune mediators in health and disease.
  • Elevated cytokine levels are implicated in the pathology of hematopoietic malignancies, including myeloproliferative neoplasms (MPNs).

Purpose of the Study:

  • To investigate plasma cytokine profiles in patients with essential thrombocythemia (ET), primary myelofibrosis (PMF), and polycythemia vera (PV).
  • To analyze correlations between cytokine levels, JAK2 V617F mutation status, and clinical-hematological parameters in MPN patients.

Main Methods:

  • Analysis of plasma cytokine profiles in patients with ET, PMF, PV, and healthy controls.
  • Correlation analysis of cytokine levels with JAK2 V617F mutation status and clinical data.

Main Results:

  • Myeloproliferative neoplasm patients showed increased levels of proinflammatory cytokines.
  • The JAK2 V617F mutation was associated with elevated Interferon-gamma-induced protein 10 (IP-10) levels in PMF patients.
  • Distinct cytokine production patterns were observed among ET, PMF, and PV patients.

Conclusions:

  • Cytokine network correlations revealed unique cytokine production patterns in ET, PMF, and PV.
  • Augmented cytokine levels are significantly associated with the physiopathology of MPNs.
Abstract

Keywords:
Inflammation, Plasma cytokinesJAK2 V617FPh-negative myeloproliferative neoplasms

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