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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Mantle cell lymphoma: from ultrasound examination to histological diagnosis
G Cocco1, A Boccatonda2, D D'Ardes1
1Unit of Internistic Ultrasound, Department of Medicine and Science of Aging, G. D'Annunzio University, Cesi-Met, via Luigi Polacchi, 66100, Chieti, CH, Italy.
Insights
Ultrasound identified unique vascular patterns in swollen lymph nodes, aiding in the early diagnosis of mantle cell lymphoma. This imaging technique offers a novel approach for detecting this specific type of lymphoma.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is a rare B-cell non-Hodgkin lymphoma.
- Diagnosis often relies on histological examination, which can be invasive.
- Imaging plays a crucial role in staging and monitoring.
Abstract:
We report the case of a 42-year-old patient referred to our department for the examination of two large, symmetrical inguinal lumps. The ultrasound examination of the swollen lymph node demonstrated a cortical echogenicity greater than the medullary echogenicity, and the vascularization stop around the cortical zone suggested a pathological pattern of mantle cell lymphoma. In this type of lymphoma, lymphocytes are localized in a mantle zone, inducing a thickening of the lumps. Therefore, for the first time, ultrasound examination detected sonographic vascular features of mantle cell lymphoma, allowing the identification of the disease and suggesting the specific histological diagnosis.
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