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Exploring the mesenteric lymphatic apparatus: A morphological and immunohistochemical investigation with clinical

L Roncati1,2,3, A Manenti1,2,4,3, T Pusiol3

  • 1Department of Diagnostic and Clinical Medicine, University of Modena and Reggio Emilia, Moderna, Italy.

Lymphology
|September 26, 2018
PubMed

Insights

Detailed immunohistochemical analysis reveals lymphatic capillaries in the mesentery and omentum lack valves, relying on external forces for lymph flow. This finding aids understanding of skip lymph node metastases.

Area of Science:

  • Anatomy
  • Physiology
  • Immunohistochemistry

Background:

  • Modern immunohistochemical techniques enable detailed lymphatic system studies.
  • The ileal and colonic mesenteries, and greater omentum, are rich in lymphatic vessels.

Purpose of the Study:

  • To conduct an in-depth study of lymphatic vessels in the ileal and colonic mesenteries and greater omentum.
  • To characterize the structure and lymph flow dynamics of these lymphatic vessels.

Main Methods:

  • Immunohistochemical analysis of lymphatic vessels.
  • Microscopic examination of mesenteric and omental lymphatic structures.

Main Results:

  • Lymphatic vessels in the studied areas are mainly capillaries interconnected with lymph nodes.
  • These capillaries have a single endothelial cell layer, a collagen membrane, and lack valves.
  • Lymph flow is propelled by external forces acting on capillary walls.
  • Collector vessels (pre- and post-lymph nodal) are observed only at mesenteric roots.

Conclusions:

  • The structural characteristics of mesenteric and omental lymphatic capillaries influence lymph flow.
  • These findings provide insights into patho-physiological correlations.
  • The study helps explain the potential for skip lymph node metastases.

Keywords:
D2-40Lymphatic vesselsimmunohistochemistrylymphatic apparatusmesenterypodoplaninskip lymph node metastasis

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