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Updated: Feb 2, 2026

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Summary of the Second Annual BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Sarah A Holstein1, J Christine Ye2, Alan Howard3

  • 1Department of Internal Medicine, Division of Oncology and Hematology, University of Nebraska Medical Center, Omaha, Nebraska.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|November 9, 2018
PubMed

Insights

The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) workshop focused on minimal residual disease (MRD) and immune profiling (IP) in myeloma. It addressed regulatory challenges for integrating these assessments into clinical trials.

Area of Science:

  • Hematology
  • Immunology
  • Clinical Trials

Background:

  • The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) convened its second annual Myeloma Intergroup Workshop.
  • The workshop focused on minimal residual disease (MRD) and immune profiling (IP) in multiple myeloma.
  • Investigators presented the latest research on assessing MRD and IP in myeloma patients.

Purpose of the Study:

  • To summarize presentations from the BMT CTN Myeloma Intergroup Workshop.
  • To review relevant abstracts from the American Society of Hematology (ASH) meeting.
  • To focus on regulatory issues concerning the integration of MRD and IP assessments in clinical trial design and practice.

Main Methods:

  • The workshop involved presentations from international investigators.
  • Relevant American Society of Hematology (ASH) abstracts were reviewed.
  • Discussions centered on regulatory aspects of MRD and IP integration.

Main Results:

  • Latest research on MRD and IP assessment in myeloma was presented.
  • Key regulatory challenges for integrating these assessments were identified.
  • The workshop provided a platform for global expert collaboration.

Conclusions:

  • Integrating MRD and IP assessment into myeloma clinical trials presents regulatory considerations.
  • Continued collaboration and research are vital for advancing myeloma treatment through MRD and IP.
  • The workshop highlighted the importance of standardized assessment methods.

Keywords:
Autologous stem cell transplantationEndpointImmune profilingMinimal residual diseaseMultiple myeloma

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