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Primary Bone Marrow Diffuse Large B-cell Lymphoma Presenting as Transverse Myelitis

Lauren Shea1, Yan Zhao2, Vishnu Reddy3

  • 1Departments of Internal Medicine.

The American Journal of the Medical Sciences
|November 19, 2018
PubMed

Insights

Primary bone marrow diffuse large B-cell lymphoma (BM-DLBCL) is a rare cancer. This study reviews 107 cases, finding it presents with cytopenias, a non-germinal center phenotype, and aggressive disease with poor survival.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Primary bone marrow diffuse large B-cell lymphoma (BM-DLBCL) is an uncommon non-Hodgkin lymphoma.
  • Prior reports are limited, necessitating further characterization of this rare entity.

Observation:

  • A case of BM-DLBCL presenting with neurologic deficits mimicking acute transverse myelitis is detailed.
  • A literature review of 107 BM-DLBCL cases was conducted.

Findings:

  • BM-DLBCL frequently presents with cytopenias and B symptoms.
  • A predominant non-germinal center phenotype is characteristic of BM-DLBCL.
  • The disease exhibits aggressive behavior, indicated by high International Prognostic Index scores and a median survival of 10.0 months.

Implications:

  • Understanding BM-DLBCL presentation and characteristics is crucial for timely diagnosis and management.
  • The aggressive nature necessitates prompt and effective therapeutic strategies.
  • Further research into optimal treatment protocols for BM-DLBCL is warranted.

Keywords:
Diffuse large B-cell lymphomaPrimary bone marrow lymphomaTransverse myelitis

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