[Lymphomatoid gastropathy: one case report and literatures review]
1Department of Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinsese Academy of Medical Sciences, Beijing 100730, China.
Insights
This study reports the first case of lymphomatoid gastropathy in China. The condition mimicked lymphoma but showed spontaneous regression, highlighting its unique nature.
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Lymphomatoid gastropathy is a rare condition.
- It can be mistaken for NK/T-cell lymphomas on pathological examination.
Observation:
- A 51-year-old female presented with epigastric discomfort and endoscopic findings of ulcers and erosions.
- Biopsies revealed atypical lymphocytes with a specific immunophenotype (CD3+, CD56+, CD20-, CD8-, TIA+, Granzyme B-, Ki-67 75%).
- Epstein-Barr virus was not detected.
Findings:
- The patient's lesions showed significant regression within four months without specific treatment.
- This suggests a benign or self-limiting course for this condition.
Implications:
- Lymphomatoid gastropathy requires careful differential diagnosis to avoid misclassification as lymphoma.
- Recognizing this entity can prevent unnecessary and potentially harmful treatments.
- Further research is needed to understand the pathogenesis and optimal management of lymphomatoid gastropathy.
Abstract:
Objective: To report the first case of lymphomatoid gastropathy in China, and to demonstrate the clinical characteristics, diagnostic approach, treatment and prognosis in this kind of patients. Methods: One patient was diagnosed as lymphomatoid gastropathy at Peking Union Medical College Hospital, and her clinical characteristics, lab data, treatment and follow-up outcomes were reviewed. Results: A case of a 51-year-old female was presented, who underwent esophagogastroduodenoscopy (EGD) due to slight epigastric discomfort. EGD revealed multiple ulcers and erosions. Biopsies showed atypical lymphocytes infiltration with CD3(+), CD56(+), CD20(-), CD8(-), TIA(+), Granzyme B(-) and Ki-67 (75%). Epstein-Barr virus-encoded RNA in situ hybridization was negative. Four months later, repeated EGD examination showed regression of the lesions without specific treatment. Conclusion: Lymphomatoid gastropathy was a unique disease entity mimicking NK/T-cell lymphomas in pathology, with the quite different profile of treatment and prognosis. It's important to consider this issue during the differential diagnosis to avoid any excessive treatment.
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