Related Experiment Video

Updated: Jan 27, 2026

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow
08:01

Fluorescence-activated Cell Sorting for Purification of Plasmacytoid Dendritic Cells from the Mouse Bone Marrow

Published on: November 4, 2016

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Blastic plasmacytoid dendritic cell neoplasm: an early presentation

Samira Oliveira Silveira, Cassia Michelle Almeida Fernandes1, Érica Baptista Pinto

  • 1Pará State University, College of Medicine, Pará. cmich.fernandes@gmail.com.

Dermatology Online Journal
|March 14, 2019
PubMed

Insights

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive skin cancer. This case highlights its rapid progression and fatal outcome, emphasizing the need for effective treatment strategies.

Area of Science:

  • Dermatology
  • Oncology
  • Hematology

Background:

  • Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy primarily affecting the skin.
  • It originates from plasmacytoid dendritic precursor cells and is characterized by rapid clinical progression.

Observation:

  • A 46-year-old woman presented with a painless, pruritic nodule on her back, which rapidly grew and spread over six months.
  • Histopathology revealed atypical lymphoid cell infiltrates in the dermis, with immunohistochemistry positive for CD45, S-100, CD123, and TCL1.
  • The patient developed dyspnea and died from cardiorespiratory arrest within 12 hours of hospital admission.

Findings:

  • The case demonstrates the aggressive nature of BPDCN, with rapid progression from cutaneous lesions to systemic compromise.
  • Immunohistochemical markers confirmed the diagnosis of BPDCN.

Implications:

  • There is currently no established consensus for BPDCN treatment.
  • Aggressive therapeutic approaches, such as intensive leukemia-like therapy and allogeneic bone marrow transplantation, may offer improved long-term survival chances.

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