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Updated: Jan 24, 2026

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision
Published on: May 2, 2025
Primary diffuse large B cell lymphoma of the common bile duct causing obstructive jaundice
Hiroaki Kato1, Masanori Tsujie1, Tomoko Wakasa2
11Department of Surgery, Nara Hospital, Kinki University Faculty of Medicine, 1248-1 Otoda-cho, Ikoma, Nara 630-0293 Japan.
Insights
This case report details a rare diffuse large B-cell lymphoma (DLBCL) originating in the common bile duct (CBD). Diagnosis required surgical resection, and the patient later succumbed to liver metastases.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is a common non-Hodgkin lymphoma.
- Primary biliary tract lymphomas are exceedingly rare.
Abstract:
We report a rare case of a diffuse large B-cell lymphoma (DLBCL) arising from the common bile duct (CBD). A 77-year old man presented with general fatigue and obstructive jaundice. Abdominal computed tomography revealed a well-circumscribed enhancing mass in the midportion of the CBD with proximal bile duct dilatation. Endoscopic retrograde cholangiopancreatography (ERCP) also showed a midportion of the CBD stricture. Direct peroral cholangioscopy revealed smooth mass in the midportion of the CBD, and narrow-band imaging (NBI) showed irregular tortuous microvessels. The brushing cytology of the CBD was performed, and it was diagnosed as suspicious for poorly differentiated adenocarcinoma or malignant lymphoma. We performed extrahepatic bile duct resection for accurate diagnosis. Histological and immunohistochemical examination of the resected specimen revealed DLBCL. Although systemic chemotherapy is the mainstay of treatment for DLBCL, he refused scheduled subsequent chemotherapy, and died of multiple liver metastases 6 months after surgery.
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