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Early Events in Lymphoid Neoplasms and Indolent Follicular Lymphomas

Sudhir Perincheri1

  • 1Department of Pathology, Yale School of Medicine, 310 Cedar Street, Suite LB20, New Haven, CT 06510, USA.

Surgical Pathology Clinics
|July 30, 2019
PubMed

Insights

New diagnostic techniques reveal early, indolent lymphoid disorders that mimic in situ lesions. Understanding these conditions is crucial to avoid overtreatment of non-progressive lymphoid conditions.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Advances in diagnostic imaging and pathology have identified early-stage indolent lymphoid disorders.
  • These lesions share similarities with in situ lesions in epithelial cancers and indolent lymphoid malignancies like chronic lymphocytic leukemia and follicular lymphoma.

Purpose of the Study:

  • To characterize newly identified indolent lymphoproliferative disorders.
  • To differentiate these indolent lesions from aggressive malignancies.
  • To guide appropriate clinical management and prevent overtreatment.

Main Methods:

  • Review of clinicopathologic features of newly characterized indolent lymphoid lesions.
  • Comparison with established indolent lymphoid malignancies.
  • Analysis of clinical course and progression patterns.

Main Results:

  • Characterization of indolent lymphoid disorders with features similar to in situ lesions.
  • Identification of indolent clinical behavior in most cases, with a low rate of progression to overt malignancy.
  • Distinction from aggressive lymphoid neoplasms based on specific clinicopathologic criteria.

Conclusions:

  • Accurate diagnosis of these indolent lymphoid lesions is essential.
  • Avoiding aggressive therapeutic regimens for non-progressive conditions is critical.
  • Further research into the specific molecular and clinical behavior of these disorders is warranted.

Keywords:
Duodenal type follicular lymphomaIn situ follicular neoplasiaIn situ lymphomaIn situ mantle cell neoplasiaIndolent follicular lymphomaMonoclonal B-cell lymphocytosis

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