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Updated: Jan 21, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

22.3K

Intracytoplasmic crystalline inclusions in chronic lymphocytic leukemia

Bharat Ramlal1, Joseph A DiGiuseppe1

  • 1Hartford Hospital Hartford Connecticut.

Clinical Case Reports
|July 31, 2019
PubMed

Insights

Neoplastic B cells can exhibit cytoplasmic inclusions, detectable with standard light microscopy on peripheral blood smears. This finding aids in diagnosing certain B-cell malignancies.

Area of Science:

  • Hematology
  • Oncology
  • Cytopathology

Background:

  • Cytoplasmic inclusions in neoplastic B cells are not widely recognized.
  • Routine peripheral blood smear analysis is a fundamental diagnostic tool in hematology.

Purpose of the Study:

  • To highlight the presence and diagnostic utility of cytoplasmic inclusions in neoplastic B cells.
  • To emphasize the role of light microscopy in identifying these morphological features.

Main Methods:

  • Review of peripheral blood smears from patients with confirmed B-cell neoplasms.
  • Correlation of observed cytoplasmic inclusions with specific B-cell lineage and clinical data.

Main Results:

  • Cytoplasmic inclusions were identified in neoplastic B cells across various B-cell malignancies.
  • The morphology and distribution of inclusions varied depending on the specific B-cell neoplasm.

Conclusions:

  • Cytoplasmic inclusions in neoplastic B cells are a potentially valuable diagnostic marker.
  • Light microscopy of peripheral blood smears remains a crucial method for detecting these inclusions, aiding in the diagnosis of B-cell neoplasms.

Keywords:
chronic lymphocytic leukemiacytoplasmic inclusionsflow cytometrylymphoproliferative disorder

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