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Improvement of biosensor accuracy using an interference index detection system to minimize the interference effects

Sungha Park1

  • 1IVD R&D Group, IVD Business Team, Health and Medical Equipment Division, Samsung Electronics Co., Ltd., 129, Samsung-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, Republic of Korea. sh8665.park@samsung.com m0855@naver.com.

The Analyst
|July 31, 2019
PubMed

Insights

Diagnostic reagent sensors can yield inaccurate patient results due to blood sample interference. An interference index detection (IID) system significantly improved measurement accuracy by minimizing effects from hemolysis and icterus.

Area of Science:

  • Clinical diagnostics
  • Biomedical engineering
  • Analytical chemistry

Background:

  • Reagent sensors are crucial in medical laboratories for patient result generation.
  • Interference from factors like hemolysis and icterus in blood samples frequently causes inaccurate diagnostic assay results.
  • Minimizing interference is essential for reliable clinical laboratory analysis.

Purpose of the Study:

  • To analyze the impact of common interferents on reagent sensors used in diagnostic assays.
  • To develop and evaluate a novel method for improving measurement accuracy in the presence of blood sample interference.
  • To introduce an interference index detection (IID) system to mitigate interference effects.

Main Methods:

  • The study involved analyzing the effects of interferents, specifically bilirubin and hemoglobin, on reagent sensors.
  • An interference index detection (IID) system was devised and implemented using a simple two-well and optical measurement setup.
  • The IID system's effectiveness was assessed by comparing results from clinical samples before and after its application.

Main Results:

  • The interference index detection (IID) system demonstrated a dramatic improvement in reducing interference rates caused by bilirubin and hemoglobin.
  • Application of the IID system led to a significant enhancement in the accuracy of measurements from clinical blood samples.
  • The IID system proved to be an effective tool for minimizing common interference issues in diagnostic assays.

Conclusions:

  • The developed interference index detection (IID) system effectively minimizes interference from common blood sample components like bilirubin and hemoglobin.
  • The IID system offers a practical and easily applicable solution for enhancing the accuracy of diagnostic reagent sensors.
  • This advancement in interference mitigation is vital for improving the reliability of patient results in medical laboratories.

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