Related Experiment Video

Updated: Jan 20, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.6K

An Uncommon Case of Double-Hit Mantle Cell Lymphoma That Demonstrates a Transformation Process

Jihao Zhou1, Lina Hu1, Min Zuo2

  • 1Department of Hematology, Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, China.

American Journal of Clinical Pathology
|August 22, 2019
PubMed

Insights

This study reports a rare case of mantle cell lymphoma (MCL) with double-hit rearrangements (CCND1/IGH and MYC/IGH). These genetic alterations likely drove the aggressive progression and transformation of MCL in this patient.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • Mantle cell lymphoma (MCL) is a mature B-cell neoplasm typically defined by the CCND1/IGH rearrangement.
  • Aggressive clinical courses in MCL can be associated with complex genetic alterations.

Observation:

  • A case of blastoid variant MCL was identified in gallbladder and bone marrow biopsies.
  • Flow cytometry revealed two distinct malignant lymphocyte populations.

Findings:

  • Fluorescence in situ hybridization (FISH) confirmed CCND1/IGH and MYC/IGH rearrangements in bone marrow samples.
  • Next-generation sequencing (NGS) detected CCND1/IGH rearrangements and TP53 mutations in both lymphocyte populations.
  • The CD19+/CD10+ cells additionally harbored MYC/IGH rearrangement and a NOTCH2 mutation.

Implications:

  • The concurrent MYC rearrangement and NOTCH2 mutation are implicated in the transformation of MCL.
  • This case highlights an uncommon double-hit MCL, illustrating a potential pathway for disease transformation.
Abstract

Keywords:
Double-hitMantle cell lymphomaTransformation

More Related Videos

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

773
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice17:59

Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice

Published on: April 3, 2011

12.7K

Related Concept Videos

Bacterial Transformation01:33

Bacterial Transformation

In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
59.5K
Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
14.3K
Transformation01:26

Transformation

Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
720
Transformers01:26

Transformers

A device that transforms voltages from one value to another using induction is called a transformer. A transformer consists of two separate coils, or windings, wrapped around the same soft iron core. However, they are electrically insulated from each other.
The iron core has a substantial relative permeability. Therefore, the magnetic field lines generated due to the current in one winding are almost entirely confined within the core, such that the same magnetic flux permeates each turn of both...
1.7K
The Ideal Transformer01:26

The Ideal Transformer

In single-phase two-winding transformers, two windings are coiled around a magnetic core characterized by cross-sectional area A and magnetic permeability μ. A phasor current i1 enters the left winding while i2 exits the right winding, establishing the fundamental working of the transformer through electromagnetic principles.
Ampere's Law forms the basis of understanding the magnetic field within the transformer. It states that the integral of the magnetic field intensity's tangential...
1.4K
Properties of the z-Transform II01:16

Properties of the z-Transform II

The property of Accumulation in signal processing is derived by analyzing the accumulated sum of a discrete-time signal and using the time-shifting property to determine its z-transform. This principle reveals that the z-transform of the summed signal is related to the z-transform of the original signal by a multiplicative factor.
Moreover, the convolution property indicates that the convolution of two signals in the time domain corresponds to the product of their z-transforms in the frequency...
392