Related Experiment Video

Updated: Jan 19, 2026

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

Published on: January 27, 2023

27.6K

IP-10 and MCP-1 gene polymorphisms in Chinese patients with chronic immune thrombocytopenia

Xian Zhang1, Donglei Zhang2,3, Huiyuan Li2

  • 1The Hematology Department, Zhongnan Hospital of Wuhan University, Wuhan, China.

Autoimmunity
|September 19, 2019
PubMed

Insights

The IFN-γ-inducible protein of 10 kilodaltons (IP-10) gene polymorphism (-201 G/A) is linked to increased susceptibility to immune thrombocytopenia (ITP) in the Chinese population. ITP patients exhibited higher IP-10 levels, particularly those with specific genotypes.

Area of Science:

  • Immunology
  • Genetics

Background:

  • Aberrant Th1/Th2 immune responses are implicated in primary immune thrombocytopenia (ITP).
  • IFN-γ-inducible protein of 10 kilodaltons (IP-10) and Monocyte chemoattractant protein-1 (MCP-1) are key mediators of Th1 and Th2 immunity, respectively.

Purpose of the Study:

  • To investigate the association between IP-10 (-201 G/A) and MCP-1 (-2518 A/G) gene polymorphisms and susceptibility to chronic ITP.
  • To evaluate serum levels of IP-10 and MCP-1 in ITP patients and healthy controls.

Main Methods:

  • Genotyping of IP-10 (-201 G/A) and MCP-1 (-2518 A/G) polymorphisms using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) in 323 ITP patients and 255 controls.
  • Quantification of serum IP-10 and MCP-1 levels via ELISA in 79 adult ITP patients and 43 healthy controls.

Main Results:

  • The AG + AA genotype of the IP-10 (-201 G/A) polymorphism was significantly more frequent in ITP patients, especially females and adults.
  • ITP patients displayed elevated serum IP-10 levels compared to controls.
  • Both heterozygote (GA) and minor allele homozygote (AA) genotypes of IP-10 were associated with higher IP-10 levels at diagnosis.
  • No significant differences in MCP-1 gene polymorphisms or serum levels were observed between ITP patients and controls.

Conclusions:

  • The IP-10 (-201 G/A) polymorphism may contribute to ITP susceptibility in the Chinese population.
  • Elevated IP-10 levels are associated with ITP and specific IP-10 genotypes.

Keywords:
IP-10Immune thrombocytopeniaMCP-1pathogenesispolymorphism

More Related Videos

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

808
Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.3K

Related Concept Videos

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis06:05

Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis

An enema is a type of traditional Chinese medicine (TCM) therapy used to treat severe acute pancreatitis (SAP). The therapy involves instilling a TCM liquid into the rectum and colon through the anus to keep the liquid in the intestine, absorbing through the intestinal mucosa. This study aims to standardize the enema procedure for SAP...
27.6K
Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

This protocol describes the specific process and efficacy of acupoint application in treating fatigue symptoms associated with chronic obstructive pulmonary...
808
Auricular Acupuncture as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Sleep Disorders05:34

Auricular Acupuncture as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Sleep Disorders

This protocol introduces an effective method to improve the sleep condition of patients with chronic obstructive pulmonary disease and alleviate cough symptoms by using auricular acupuncture techniques to percutaneously stimulate specific acupoints in the patients' ears.
3.3K
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

In the present study, we describe a methodology to analyze the C924T genotype. The protocol consists of three phases: DNA extraction, amplification by polymerase chain reaction (PCR), and analysis of the restriction fragment length polymorphism (RFLP) on agarose...
10.4K
Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment05:58

Digital Handwriting Analysis of Characters in Chinese Patients with Mild Cognitive Impairment

This study proposed a digital handwriting analysis of characters in individuals with mild cognitive impairment to find more information than is revealed by traditional pencil–paper handwriting...
5.0K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Here, we describe an innovative method to determine complement receptor 1 (CR1) length polymorphisms for use in several applications, particularly the assessment of susceptibility to diseases such as Alzheimer's disease (AD). This method could be useful to better understand the role of CR1 isoforms in the pathogenesis of...
12.2K