dic(7;9)(p11.1;p11.1) and del(7)(q36) as a Primary Abnormality in Childhood B-cell Precursor ALL: A Case Report

Area of Science:

• Hematology
• Genetics
• Pediatric Oncology

Background:

• B-cell acute lymphoblastic leukemia (B-ALL) involves abnormal B-lymphoblast proliferation.
• FAB classification (L1/L2) describes B-ALL cell morphology.
• Genetic classification of B-ALL relies on molecular cytogenetic and molecular testing.

Purpose of the Study:

• To report a pediatric B-ALL case with a primary dic(7;9)(p11.1;p11.1) and CUL1 deletion (7q36).
• To highlight the patient's response to standard risk induction therapy despite poor prognostic markers.

Main Methods:

• Conventional karyotyping and fluorescence in situ hybridization (FISH) were used for genetic abnormality detection.
• Minimal residual disease monitoring assessed treatment response.

Main Results:

• The pediatric B-ALL case presented with dic(7;9)(p11.1;p11.1) and CUL1 deletion (7q36).
• Both 7p and 9p deletions are typically associated with poor prognosis.
• The patient exhibited a favorable response to standard risk induction therapy.

Conclusions:

• This case demonstrates that pediatric B-ALL with dic(7;9) and CUL1 deletion can respond well to standard treatment.
• Genetic abnormalities, even those linked to poor prognosis, require careful correlation with clinical response.