Related Experiment Video

Updated: Dec 31, 2025

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
07:53

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium

Published on: January 16, 2018

8.6K

Intraflagellar transport 20: New target for the treatment of ciliopathies

Ming-Hui Zhou1, Yi Lin1, Zhen-Gang Zhang1

  • 1Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Biochimica Et Biophysica Acta. Molecular Cell Research
|January 2, 2020
PubMed

Insights

Intraflagellar transport 20 (IFT20) is crucial for cilia formation and its defects link to many diseases. This review highlights IFT20

Area of Science:

  • Cell Biology
  • Genetics
  • Biochemistry

Background:

  • Cilia are vital cellular structures in mammals, essential for various physiological processes.
  • Proper cilia formation relies on the intracellular ciliary transport system.
  • Disruptions in cilia function are implicated in numerous human diseases.

Purpose of the Study:

  • To review the current research on Intraflagellar transport 20 (IFT20).
  • To elucidate the role of IFT20 in cilia formation and assembly.
  • To identify potential therapeutic targets for ciliary dysplasia-related diseases.

Main Methods:

  • Literature review of studies on IFT20 and ciliary function.
  • Analysis of research linking IFT20 defects to various disease systems.
  • Synthesis of information on IFT20's role in cilia biogenesis.

Main Results:

  • IFT20 is a key component of Intraflagellar Transport (IFT) complex B.
  • Defects in IFT20 are associated with a wide range of systemic diseases, including those affecting the urinary, cardiovascular, skeletal, nervous, immune, reproductive, and respiratory systems.
  • IFT20 plays a critical role in the proper formation and function of cilia.

Conclusions:

  • IFT20 is indispensable for normal cilia development and function.
  • Understanding IFT20's role provides insights into the pathogenesis of ciliary diseases.
  • IFT20 represents a promising target for developing novel therapeutic strategies for ciliary dysfunction.

Keywords:
CiliaCiliopathiesIntraflagellar transportIntraflagellar transport 20

More Related Videos

Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons07:35

Immobilization of Caenorhabditis elegans to Analyze Intracellular Transport in Neurons

Published on: October 18, 2017

8.4K
Expanding the Toolkit for In Vivo Imaging of Axonal Transport09:24

Expanding the Toolkit for In Vivo Imaging of Axonal Transport

Published on: December 23, 2021

3.9K

Related Concept Videos

Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
9.9K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
4.7K
Microtubules in Signaling01:22

Microtubules in Signaling

The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
2.0K
The Movement of Organelles and Vesicles01:43

The Movement of Organelles and Vesicles

In eukaryotic cells,  cytoskeletal filaments such as actin, microtubules, and intermediate filaments form a mesh-like cytoskeletal network. These filaments serve as tracks for transporting cellular cargo. Specialized motor proteins use the chemical energy stored in adenosine triphosphate (ATP) for this transport. During interphase, microtubules are polarized, with the plus-end towards the cell periphery and the minus-end towards the cell center. Two microtubule-associated motor proteins,...
5.8K
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
11.7K
Protein Transport into the Inner Mitochondrial Membrane01:34

Protein Transport into the Inner Mitochondrial Membrane

Nuclear encoded mitochondrial precursors are imported to the inner membrane in a multistep process involving two separate translocons, TIM22 and TIM23. TIM23 is a cation-selective pore that remains closed by the N terminal segment of the protein. Negative charges on the TIM23 act as a receptor for the incoming precursor, pulling the positively charged matrix-targeting sequence for peptide insertion and translocation.
Transport of mitochondrial precursors across the TIM23 channel is driven by...
4.7K