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Immune cell regulation of the hair cycle

Etienne C E Wang1, Claire A Higgins2

  • 1Skin Research Institute of Singapore (SRIS), National Skin Centre, Singapore, Singapore.

Experimental Dermatology
|January 7, 2020
PubMed

Insights

Understanding immune cells

Area of Science:

  • Dermatology and immunology, focusing on skin biology and hair follicle research.

Background:

  • Mammalian hair cycle manipulation offers potential for novel alopecia therapies.
  • Niche and microenvironmental signals are crucial alongside epithelial-mesenchymal interactions.
  • Immune cells are increasingly recognized for their role in skin homeostasis and hair cycling.

Purpose of the Study:

  • To review the current understanding of immune cells in mammalian hair cycle control.
  • To discuss the relevance of immune cells to human hair cycling disorders.
  • To explore new avenues for hair regeneration and ex vivo hair growth models.

Main Methods:

  • Literature review summarizing existing research on immune cells and the hair cycle.
  • Analysis of immune cell involvement in different hair cycle phases (growth, regression, rest).
  • Discussion of implications for human alopecia and hair growth research.

Main Results:

  • Immune cells play a significant, previously underestimated role in regulating the mammalian hair cycle.
  • Specific immune cell populations and their interactions influence hair follicle activity.
  • Dysregulation of immune cells is linked to various human hair loss conditions.

Conclusions:

  • Targeting immune cells presents a promising strategy for treating alopecia.
  • Further research into immune cell functions can enhance hair regeneration therapies.
  • Understanding these interactions is key to developing improved ex vivo hair growth models.

Keywords:
T cellsanagencatagenmacrophagesmast cellstelogen

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