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Pathology of Idiopathic Interstitial Pneumonias

Yoshiaki Zaizen1, Junya Fukuoka2

  • 1Department of Pathology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan; Division of Respirology, Neurology and Rheumatology, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan.

Surgical Pathology Clinics
|February 2, 2020
PubMed

Insights

This review explains diagnostic pathology for idiopathic interstitial pneumonias (IIPs). Understanding lung lobule anatomy is key for diagnosing IIPs, especially usual interstitial pneumonia, using pathology methods.

Area of Science:

  • Pulmonology
  • Pathology
  • Anatomy

Background:

  • Idiopathic interstitial pneumonias (IIPs) require accurate diagnosis.
  • Understanding lung lobule structure is crucial for pathology diagnosis.
  • Tissue acquisition methods can impact diagnostic accuracy.

Purpose of the Study:

  • To review diagnostic pathology in idiopathic interstitial pneumonias (IIPs).
  • To emphasize the importance of lung lobule anatomy in IIP diagnosis.
  • To focus on the diagnosis of usual interstitial pneumonia.

Main Methods:

  • Review of fundamental lung anatomy and interstitial pneumonia.
  • Discussion of various histologic types of IIPs.
  • Emphasis on diagnostic challenges related to tissue acquisition, including cryobiopsy limitations.

Main Results:

  • Accurate identification of abnormality location within lung lobules is critical for IIP diagnosis.
  • Newer techniques like cryobiopsy have limitations in lobule coverage.
  • Histologic patterns of IIPs are presented, with a focus on usual interstitial pneumonia.

Conclusions:

  • A thorough understanding of lung lobule anatomy is essential for accurate IIP diagnosis.
  • Pathologists must consider tissue acquisition methods and their impact on diagnosis.
  • Usual interstitial pneumonia diagnosis is clinically significant and requires careful pathological assessment.

Keywords:
ClassificationGuidelineIdiopathic pulmonary fibrosisInterstitial lung disease

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