Related Experiment Video

Updated: Dec 28, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.4K

Serum Soluble CD89-IgA Complexes Are Elevated in IgA Nephropathy without Immunosuppressant History

Haiting Wu1, Xiaoyan Wang2,3, Zhe Yang2

  • 1Division of Nephrology, Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Disease Markers
|February 21, 2020
PubMed

Insights

Serum soluble CD89-IgA complexes can aid in diagnosing IgA nephropathy (IgAN) in patients not on immunosuppressants. However, these complexes offer limited value for predicting disease severity.

Area of Science:

  • Immunology
  • Nephrology
  • Biochemistry

Background:

  • CD89 (FcαRI) is the IgA receptor, and its soluble form (sCD89) can complex with IgA in serum.
  • These sCD89-IgA complexes are implicated in the pathogenesis of IgA nephropathy (IgAN).
  • Previous studies on the clinical utility of sCD89-IgA complexes have yielded conflicting results.

Purpose of the Study:

  • To investigate the diagnostic and evaluative potential of serum sCD89-IgA complexes in IgA nephropathy.
  • To determine if sCD89-IgA complex levels correlate with disease severity in IgAN patients.

Main Methods:

  • A sandwich ELISA was developed using anti-CD89 capture antibodies and HRP-conjugated anti-IgA detection antibodies.
  • Serum levels of sCD89-IgA complexes were measured in IgAN patients (without prior immunosuppressant treatment) and healthy controls.
  • Correlations between sCD89-IgA complex levels and clinicopathological features of IgAN were analyzed.

Main Results:

  • Serum sCD89-IgA complex levels showed a positive correlation with age.
  • IgAN patients exhibited significantly higher serum sCD89-IgA complex levels compared to age- and gender-matched healthy individuals.
  • The study found higher sCD89-IgA complex levels in IgAN patients compared to controls.

Conclusions:

  • Serum sCD89-IgA complexes show promise as a diagnostic biomarker for IgA nephropathy in treatment-naïve patients.
  • The utility of sCD89-IgA complexes for clinicopathological prediction in IgAN appears limited.
Abstract

More Related Videos

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy14:18

Author Spotlight: Investigating the Potential of Chinese Herbal Medicinal Active Dioscin in Treating IgA Nephropathy

Published on: October 13, 2023

2.2K
Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

2.1K

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
416
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
154
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.9K
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
217
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
301
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
233