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CD2 Immunobiology

Christian Binder1,2, Filip Cvetkovski2, Felix Sellberg1,2

  • 1Department of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala University, Uppsala, Sweden.

Frontiers in Immunology
|June 26, 2020
PubMed

Insights

The CD2 receptor on T cells is crucial for immune responses and memory T cell activation. Targeting the CD2/LFA3 pathway with biologics offers a promising strategy for treating T cell-related disorders.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Glycoprotein CD2 is a costimulatory receptor on T and NK cells, binding LFA3 on antigen-presenting cells.
  • CD2 is vital for immunological synapse formation, organization, and intracellular signaling during T cell-APC conjugation.
  • CD2 expression elevates on memory and activated T cells, significantly impacting memory T cell activation.

Purpose of the Study:

  • To highlight the significance of the CD2/LFA3 costimulatory pathway in T cell activation.
  • To explore the therapeutic potential of targeting CD2 for immune modulation.
  • To emphasize CD2 as an attractive target for monoclonal antibody development.

Main Methods:

  • Review of existing literature on CD2 function and its role in T cell activation.
  • Analysis of studies involving anti-CD2 monoclonal antibodies and CD2-targeting biologics.
  • Evaluation of clinical data on the safety and efficacy of CD2-targeting therapies.

Main Results:

  • CD2 plays a key role in memory T cell activation, even with other costimulatory pathways present.
  • Anti-CD2 antibodies demonstrate immunomodulatory effects in vitro.
  • Clinical studies confirm the safety and efficacy of CD2-targeting biologics.
  • The CD2/LFA3 pathway is identified as a potentially overlooked therapeutic target.

Conclusions:

  • CD2 is a valuable target for monoclonal antibodies in treating conditions with aberrant T cell activation.
  • Targeting CD2 allows for selective engagement of memory T cells.
  • CD2-based therapies may promote immune regulation and offer a novel treatment avenue.

Keywords:
AlefaceptCD2CD58LFA-3 (lymphocyte functional antigen-3)T cell activationcostimulationcostimulation blockadesiplizumab

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