Mantle Cell Lymphoma Presenting as a Subcutaneous Mass of the Right Leg

Area of Science:

• Hematology
• Oncology
• Pathology

Background:

• Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin lymphoma.
• MCL typically presents with widespread disease, including lymphadenopathy, bone marrow, and spleen involvement.
• Extranodal manifestations of MCL are recognized but less common.

Observation:

• A 73-year-old male patient presented with a 6-month history of a subdermal mass.
• The mass was located on the right upper thigh.
• The patient reported no systemic symptoms at the time of presentation.

Findings:

• The subdermal mass was diagnosed as Mantle cell lymphoma (MCL).
• This case represents an unusual extranodal presentation of MCL.
• The absence of typical systemic symptoms complicated the initial diagnosis.

Implications:

• Highlights the importance of considering rare presentations of MCL, even without systemic symptoms.
• Suggests that localized extranodal masses can be the primary manifestation of MCL.
• Underscores the need for thorough diagnostic evaluation of unexplained masses.