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Updated: Dec 3, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
Endoscopic diagnosis of primary and recurrent mantle cell lymphomas
Miguel Mascarenhas Saraiva1, Tiago Filipe Ribeiro2, Amadeu Corte Real Nunes2
1Gastroenterology, Centro Hospitalar Universitário de São João, Portugal.
Insights
A 64-year-old man was diagnosed with mantle-cell lymphoma (MCL) presenting as a gastric ulcer. This rare presentation highlights the importance of considering lymphoma in unexplained gastrointestinal symptoms.
Area of Science:
- Gastroenterology
- Hematology
- Oncology
Background:
- Mantle-cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma.
- Gastric involvement by MCL is uncommon, often presenting with non-specific symptoms.
Abstract:
A 64-year-old male presented to our center with epigastric pain, anorexia, fatigue, weight loss and anemia on a laboratory study. An abdominal ultrasound revealed thickening of the gastric walls. Upper endoscopy demonstrated a 40 mm ulcerated lesion at the incisura angularis. A biopsy of the lesion revealed a lymphocytic infiltrate expressing CD5, CD20 and cyclin D1, typical of mantle-cell lymphoma (MCL).

