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Updated: Nov 27, 2025

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
08:53

Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma

Published on: June 10, 2017

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Hodgkin Reed-Sternberg-Like Cells in Non-Hodgkin Lymphoma

Paola Parente1, Magda Zanelli2, Francesca Sanguedolce3

  • 1Pathology Unit, Fondazione IRCCS Ospedale Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Italy.

Diagnostics (Basel, Switzerland)
|December 2, 2020
PubMed

Insights

Reed-Sternberg-like cells (RSLCs) can appear in non-Hodgkin lymphomas (NHLs), mimicking classic Hodgkin lymphoma (cHL) cells. Distinguishing RSLCs in NHLs from true Reed-Sternberg cells in cHL is crucial for appropriate treatment.

Area of Science:

  • Hematopathology
  • Oncology
  • Immunophenotyping

Background:

  • Reed-Sternberg cells (RSCs) are characteristic of classic Hodgkin lymphoma (cHL).
  • Similar cells, termed Reed-Sternberg-like cells (RSLCs), can be found in non-Hodgkin lymphomas (NHLs).
  • RSLCs in NHLs often lack the typical cHL microenvironment and appear as scattered cells or small clusters.

Purpose of the Study:

  • To describe NHL subtypes where RSLCs are detected.
  • To correlate RSLC presence with clinicopathological features in NHLs.
  • To provide diagnostic clues for differentiating RSLCs in NHLs from RSCs in cHL.

Main Methods:

  • Morphological and immunophenotypic analysis of RSLCs in NHLs.
  • Review of clinicopathological data associated with RSLC-positive NHLs.
  • Comparative analysis of RSLCs and RSCs.

Main Results:

  • RSLCs in NHLs share immunophenotypic similarities with RSCs (CD30+, EBV+, often B-cell markers, CD45-/LCA-).
  • RSLCs in NHLs are typically found as isolated or clustered cells, distinct from the cHL background.
  • Specific NHL entities harboring RSLCs were identified and characterized.

Conclusions:

  • Accurate distinction between cHL and NHLs with RSLCs is essential due to differing therapeutic strategies.
  • Understanding the clinicopathological context and immunophenotype aids in differentiating RSLCs in NHLs from RSCs in cHL.
  • This review highlights key features for diagnosing NHLs presenting with RSLCs.

Keywords:
B cell lymphomaCD30Reed-Sternberg cellReed-Sternberg-like cellT cell lymphomaclassic Hodgkin Lymphomalymphoma diagnosislymphoma diagnostics

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