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[Utility of core-needle biopsy as a primary diagnostic method for detecting aggressive B-cell lymphoma in the

Hiroya Namiki1, Yuta Ito1,2, Haruka Matsuzawa3

  • 1Division of Clinical Oncology/Hematology, Department of Internal Medicine, The Jikei University Kashiwa Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|February 8, 2021
PubMed

Insights

Core-needle biopsy (CNB) is a safe and effective diagnostic tool for critically ill patients with suspected malignant lymphoma. This procedure provided a rapid diagnosis, enabling prompt chemotherapy and a complete patient response.

Area of Science:

  • Oncology
  • Diagnostic Imaging
  • Pathology

Background:

  • Malignant lymphoma can present with non-specific symptoms like appetite loss and abdominal distention.
  • Computed tomography (CT) scans are crucial for initial diagnosis, revealing masses and ascites.
  • Critically ill patients may pose challenges for traditional diagnostic procedures.

Observation:

  • A 68-year-old male presented with symptoms suggestive of malignancy.
  • CT scan identified an ileocecal mass and significant ascites, consistent with lymphoma.
  • The patient's condition deteriorated, necessitating intensive care unit (ICU) admission and intubation.

Findings:

  • Core-needle biopsy (CNB) was successfully performed on a peritoneal mass in the ICU.
  • Pathological analysis of the CNB revealed diffuse infiltration of CD20+ middle-sized lymphoid cells, confirming malignant lymphoma.
  • The patient achieved a complete response after initiating chemotherapy.

Implications:

  • Core-needle biopsy (CNB) is feasible and safe, even in critically ill patients requiring intensive care.
  • Rapid diagnosis via CNB facilitates timely initiation of appropriate treatment, such as chemotherapy.
  • This approach can significantly improve outcomes for patients with advanced malignant lymphoma.

Keywords:
Aggressive B-cell lymphomaCore-needle biopsyDiagnosis

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