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The role of CD38 in HIV infection

Liqi Lu1, Jie Wang1, Qian Yang2

  • 1Department of Transfusion, The Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, Sichuan, 646000, People's Republic of China.

AIDS Research and Therapy
|April 6, 2021
PubMed

Insights

CD38, a molecule regulating cell states, impacts HIV infection progression. Understanding its role in CD4+ T cells may reveal new HIV treatment strategies.

Area of Science:

  • Immunology
  • Molecular Biology
  • Virology

Background:

  • CD38 is a widely-expressed transmembrane glycoprotein involved in cell differentiation and activation.
  • It possesses diverse functions, including enzymatic activity, signal transduction, and cytokine production.
  • CD38 plays a significant role in various physiological and pathological processes, including disease progression.

Purpose of the Study:

  • To summarize the current understanding of CD38's role in HIV infection.
  • To explore potential mechanisms by which CD38 influences HIV progression.
  • To discuss the specific involvement of CD38 in the infection of human CD4+ T lymphocytes by HIV.

Main Methods:

  • Literature review of existing studies on CD38 and HIV infection.
  • Analysis of CD38's functions in cellular processes relevant to HIV.
  • Focus on CD38's impact on CD4+ T cell susceptibility and HIV pathogenesis.

Main Results:

  • CD38 is implicated in the occurrence and development of HIV infection.
  • Multiple mechanisms suggest CD38 influences HIV progression.
  • CD38's role in human CD4+ T lymphocyte infection by HIV is a key area of investigation.

Conclusions:

  • Investigating CD38's function in HIV infection offers novel therapeutic perspectives.
  • Targeting CD38 pathways could be a potential strategy for HIV treatment.
  • Further research into CD38's specific role in CD4+ T cells is warranted.

Keywords:
ARTAbnormal immune activationCD38 moleculeHIV

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