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Necrotizing Cellulitis and Myositis in a Neutropenic Leukemic Patient

Akankcha Alok1,2, John Greene3

  • 1Infectious Disease, Moffitt Cancer Center, Tampa, USA.

Cureus
|June 14, 2021
PubMed

Insights

This case highlights pyoderma gangrenosum (PG) in a neutropenic patient. Early diagnosis and treatment of PG are crucial for preventing severe complications.

Area of Science:

  • Dermatology
  • Hematology
  • Infectious Diseases

Background:

  • Necrotizing infections and pyoderma gangrenosum (PG) present diagnostic challenges, especially in immunocompromised patients.
  • Neutropenic leukemic patients are susceptible to severe infections and atypical dermatological conditions.

Observation:

  • A case of necrotizing cellulitis and myositis was observed in a neutropenic leukemic patient.
  • The patient presented with enlarging, sterile, necrotic lesions unresponsive to antibiotics.

Findings:

  • Investigations led to the diagnosis of pyoderma gangrenosum (PG).
  • The patient's condition improved significantly with appropriate PG-directed treatment.

Implications:

  • Pyoderma gangrenosum (PG) should be considered in the differential diagnosis of unexplained necrotic skin lesions in neutropenic patients.
  • Prompt recognition and management of PG are essential to prevent deep tissue infection, chronic wounds, and disfigurement.

Keywords:
angioimmunoblastic lymphadenopathy with dysproteinemiaecthyma gangrenosumimmunosuppressedinfectionsleukemia cutispyoderma gangrenosumsweet syndrome

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