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Blastic plasmacytoid dendritic cell neoplasm with cutaneous presentation: A case series in children
Grace Chan1, Similolu Akintorin2, Minnelly Luu3,4
1Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Insights
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare skin cancer. This study details three pediatric BPDCN cases, emphasizing diverse skin and clinical signs in children.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive hematologic malignancy.
- BPDCN primarily affects the skin but can involve multiple organs.
- Pediatric BPDCN is exceptionally rare, with fewer than 90 cases reported.
Observation:
- This report presents three pediatric cases of BPDCN.
- The cases illustrate the varied cutaneous and clinical presentations of the disease in children.
- Observations highlight the diagnostic challenges and diverse manifestations.
Findings:
- Pediatric BPDCN can present with distinct dermatological findings.
- Clinical heterogeneity is observed in affected children.
- Early recognition of variable signs is crucial for timely diagnosis.
Implications:
- Understanding the variable presentation of pediatric BPDCN is essential for early diagnosis and treatment.
- Increased awareness among clinicians can improve patient outcomes.
- Further research into pediatric BPDCN is warranted to improve management strategies.
Abstract:
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare, aggressive hematologic malignancy that can present with multiorgan involvement including the skin. While this entity accounts for 0.1% of all cutaneous lymphomas in adults, fewer than 90 pediatric cases have been described in the literature. We present three cases of pediatric BPDCN, highlighting the variable cutaneous and clinical presentation.
