Related Experiment Video

Updated: Oct 27, 2025

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

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41-year-old male with a pituitary mass

Wenjuan Wen1, Leiming Wang2, Mengyou Li3

  • 1Department of Pathology, Liaocheng People's Hospital, Liaocheng, China.

Brain Pathology (Zurich, Switzerland)
|July 21, 2021
PubMed

Insights

This study identifies a sellar lesion with two distinct cell types. One component is CD20-positive, characteristic of B-cell lymphoma, while the other expresses Pit-1 and CK18, suggesting a pituitary origin.

Area of Science:

  • Neuro-oncology
  • Endocrinology
  • Pathology

Background:

  • Sellar region lesions can present diagnostic challenges, requiring detailed histopathological analysis.
  • Distinguishing between primary pituitary tumors and other sellar masses is crucial for appropriate management.

Observation:

  • Magnetic resonance imaging revealed an irregular sellar lesion.
  • Histological examination showed two distinct cell populations: one with features of lymphoma (CD20+) and another with characteristics of pituitary cells (Pit-1+, CK18+).

Findings:

  • The co-existence of a CD20-positive lymphoid component and a Pit-1/CK18-positive epithelial component within a sellar lesion was identified.
  • Immunohistochemistry confirmed the dual nature of the tumor, highlighting specific markers for each cell type.

Implications:

  • This case highlights a rare biphenotypic or collision tumor in the sellar region.
  • Accurate diagnosis is essential for guiding treatment strategies and predicting patient outcomes for sellar masses.

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