Related Experiment Video

Updated: Oct 27, 2025

Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors
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Enrichment and Characterization of the Tumor Immune and Non-immune Microenvironments in Established Subcutaneous Murine Tumors

Published on: June 7, 2018

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Immune Microenvironment Features and Dynamics in Hodgkin Lymphoma

Clara Bertuzzi1, Elena Sabattini1, Claudio Agostinelli1,2

  • 1Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Cancers
|July 24, 2021
PubMed

Insights

Classical Hodgkin's lymphoma (cHL) involves unique Reed-Sternberg cells interacting with the tumor microenvironment. This microenvironment influences cHL development and offers potential therapeutic targets.

Area of Science:

  • Oncology
  • Immunology
  • Pathogenesis

Background:

  • Classical Hodgkin's lymphoma (cHL) comprises 10% of lymphoma diagnoses.
  • cHL is characterized by Hodgkin cells (HCs) and Reed-Sternberg cells (HRSCs) within a reactive microenvironment (ME).
  • HRSCs modulate the ME by releasing cytokines, influencing immune cell function and promoting tumor survival.

Purpose of the Study:

  • To review the role of the ME in cHL pathogenesis and prognosis.
  • To explore the ME as a potential therapeutic target in cHL.

Main Methods:

  • Literature review focusing on the interaction between HRSCs and the ME.
  • Analysis of cytokine production and immune cell modulation within the cHL microenvironment.

Main Results:

  • The ME plays a critical role in cHL pathogenesis by supporting tumor cell survival and immune evasion.
  • HRSCs actively shape the ME, creating a niche that favors tumor progression.
  • Immune cell populations are functionally altered within the ME to provide prosurvival signals to cancer cells.

Conclusions:

  • The reactive microenvironment is integral to the development and progression of cHL.
  • Targeting the ME presents a promising therapeutic strategy for cHL treatment.

Keywords:
Hodgkin lymphomaimmune escapeimmune surveillancemicroenvironment

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