Related Experiment Video

Updated: Oct 23, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

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Perpetually Positive: Post-COVID Interstitial Lung Disease in an Immunocompromised Patient With Diffuse Large B-cell

John S Dayco1, Zeinab El-Reda1, Nabeel Sumbal2

  • 1Wayne State University, Detroit, MI, USA.

Journal of Investigative Medicine High Impact Case Reports
|August 24, 2021
PubMed

Insights

This case report details Post-COVID Interstitial Lung Disease (PC-ILD), a severe complication in a patient with lymphoma. It highlights the challenges in managing prolonged COVID-19 infection and immune response.

Area of Science:

  • Pulmonology
  • Infectious Diseases
  • Oncology

Background:

  • Long-term complications of COVID-19 infection are increasingly recognized.
  • Post-COVID Interstitial Lung Disease (PC-ILD) is a serious sequela affecting patient recovery.
  • Understanding PC-ILD pathophysiology is crucial for managing vulnerable populations.

Observation:

  • A case report of a patient with diffuse large B-cell lymphoma who developed PC-ILD.
  • The patient experienced a prolonged COVID-19 polymerase chain reaction (PCR) positivity exceeding 3 months.
  • A complex hospital course involved challenges in immune response and medical decision-making.

Findings:

  • The study explores the physiological response to SARS-CoV-2 and inadequate immune response in the patient.
  • Pathophysiology of PC-ILD is detailed and correlated with serial computed tomographic (CT) imaging over 3 months.
  • CT scans revealed progressive interstitial lung changes consistent with PC-ILD.

Implications:

  • This case underscores the need for vigilance among healthcare providers regarding severe COVID-19 complications.
  • Highlights the importance of early recognition and management of PC-ILD in immunocompromised patients.
  • Informs clinical practice for protecting vulnerable patient groups from severe post-viral lung disease.

Keywords:
geriatricshematologyimmunologyinfectious diseaseoncologyradiology/imaging

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