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Updated: Oct 18, 2025

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
COVID-19 vaccine induced interstitial lung disease
Ayumi Yoshifuji1, Kota Ishioka1, Yuya Masuzawa2
1Department of Internal Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Insights
A rare case of drug-induced interstitial lung disease (DIILD) occurred after COVID-19 vaccination. Early diagnosis and glucocorticoid treatment are vital for managing this vaccine complication.
Area of Science:
- Pulmonology
- Immunology
- Vaccinology
Background:
- COVID-19 vaccines are crucial for pandemic control.
- Adverse pulmonary events post-vaccination are rare but require investigation.
- Interstitial lung disease (ILD) is a potential, albeit uncommon, complication.
Abstract:
A 60-year-old man presented with dyspnea four days after the second dose of the coronavirus disease (COVID-19) vaccine. Imaging revealed extensive ground-glass opacification. Blood tests were notable for elevated KL-6 levels. Bronchoalveolar lavage fluid analysis showed increased lymphocyte-dominant inflammatory cells and decreased CD4/CD8 ratio. These findings were consistent with the diagnosis of drug-induced interstitial lung disease (DIILD). To the best of our knowledge, this has never been reported in previous literature. Treatment with glucocorticoids relieved his symptoms. This paper highlights that although extremely rare, COVID-19 vaccine could cause DIILD, and early diagnosis and treatment are crucial to improve patient outcomes.
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