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Updated: Oct 18, 2025

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
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The first description of a singular case of synchronous chronic myelomonocytic leukemia and diffuse large b-cell

Alessandra Romano1, Michele Giusti2,3, MaryAnn Di Giorgio4

  • 1Dipartimento di Chirurgia e Specialità Medico Chirurgiche Sezione di Ematologia Università degli Studi di Catania Catania Italy.

Clinical Case Reports
|September 30, 2021
PubMed

Insights

Neoplastic monocytes in chronic myelomonocytic leukemia (CMML) are identifiable by immunophenotype. Myeloid growth factors are safe supportive care for extranodal non-Hodgkin Lymphoma.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder.
  • Neoplastic monocytes are a hallmark of CMML, but their precise identification can be challenging.
  • Extranodal non-Hodgkin Lymphoma (NHL) can occur concomitantly with CMML.

Keywords:
CMMLR‐CHOPfilgrastimlymphomamonocytessupportive care

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