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Immunobiological Properties and Clinical Applications of Interleukin-38 for Immune-Mediated Disorders: A Systematic

Abdolreza Esmaeilzadeh1,2,3, Nazila Bahmaie4,5,6,7, Elham Nouri8,9

  • 1Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan 4513956111, Iran.

International Journal of Molecular Sciences
|November 27, 2021
PubMed

Insights

Interleukin-38 (IL-38) plays a key role in immune-mediated disorders, showing anti-inflammatory effects. Further research into IL-38's immunomodulatory properties could improve diagnosis and treatment outcomes for autoimmune diseases.

Area of Science:

  • Immunology
  • Biomarkers
  • Therapeutics

Background:

  • Cytokines, including interleukin-38 (IL-38), are increasingly used as seroimmunobiomarkers for improved diagnostics and therapeutics.
  • IL-38 has been implicated in various immunopathophysiological and immunopathological processes.
  • Understanding IL-38's role is crucial for advancing immune-mediated disorder management.

Purpose of the Study:

  • To provide a comprehensive overview of interleukin-38 (IL-38).
  • To explore IL-38's immunobiological mechanisms, diagnostic potential, and immune gene-based therapeutic applications.
  • To synthesize current knowledge on IL-38's role in health and disease.

Main Methods:

  • Systematic review of 216 articles.
  • Literature search conducted from January 2012 to July 2021.
  • Utilized six main keywords for comprehensive data retrieval.

Main Results:

  • IL-38 functionality is influenced by microenvironments, dosage, and receptor interactions.
  • Altered serum levels of IL-38 are significant in the immunopathogenesis of immune-mediated disorders.
  • IL-38 exhibits anti-inflammatory activity by inhibiting pro-inflammatory cytokines, suggesting therapeutic potential in autoimmune diseases.

Conclusions:

  • IL-38 demonstrates significant anti-inflammatory properties beneficial for autoimmune conditions.
  • Manipulation of IL-38's immunomodulatory effects may enhance diagnostic accuracy and clinical outcomes.
  • Interdisciplinary collaboration is essential to further elucidate IL-38's role and applications.

Keywords:
biomarkerclinical applicationsdiagnosisimmunobiologyimmunopathophysiologyinterleukin-38

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