T-Cell Large Granular Lymphocytic Leukemia: A First Case Report Diagnosed by Flow Cytometry in Vietnam
Do T Vinh An1, Le Lan Anh1, Nguyen Tuan Tung1
1Hematology and Blood Transfusion, Bach Mai Hospital, Hanoi, VNM.
Insights
T-cell large granular lymphocytic leukemia is a rare blood cancer. It involves clonal T-cell large granular lymphocytes in the blood and bone marrow, often with a CD4-/CD8+ immunophenotype.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- T-cell large granular lymphocytic leukemia (T-LGL leukemia) is a rare, chronic lymphoproliferative disorder.
- It is characterized by the infiltration of clonal large granular lymphocytes (LGLs) in the peripheral blood and bone marrow.
Observation:
- The neoplastic cells in T-LGL leukemia exhibit a mature T-cell immunophenotype.
- A significant majority of cases present with a CD4-/CD8+ T-cell immunophenotype.
Findings:
- The study focuses on the immunophenotypic characteristics of T-LGL leukemia.
- The predominant immunophenotype observed is CD4-/CD8+ T-cell receptor (TCR) subset.
Implications:
- Understanding the immunophenotype is crucial for accurate diagnosis and classification of T-LGL leukemia.
- This detailed characterization aids in differentiating T-LGL leukemia from other lymphoid disorders.
Abstract:
T-cell large granular lymphocytic leukemia (T-LGL leukemia) is a rare, chronic lymphoproliferative disorder in the peripheral blood. This is characterized by peripheral blood and bone marrow (BM) lymphocytic infiltration with clonal large granular lymphocytes (LGLs). The neoplastic cells of this disease display a mature T-cell immunophenotype, with the majority of cases showing a CD4-/CD8+ T-cell, T-cell receptor (TCR) subset immunophenotype versus other permutations of those markers.
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