Related Experiment Video

Updated: Oct 8, 2025

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
09:53

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus

Published on: August 25, 2017

8.4K

Cellulitis in patients with chronic lower-limb lymphedema due to HIV-related Kaposi sarcoma

Patricia Volkow-Fernández1, Beda Islas-Muñoz1, Pamela Alatorre-Fernández1

  • 1Department of Infectious Diseases, 42597Instituto Nacional de Cancerología (INCan), México.

International Journal of STD & AIDS
|December 30, 2021
PubMed

Insights

Chronic lower limb lymphedema (CL-LL) from Kaposi sarcoma (KS) increases cellulitis risk and complications. Antimicrobial prophylaxis may prevent severe outcomes in these HIV patients.

Area of Science:

  • Oncology
  • Infectious Diseases
  • Dermatology

Background:

  • Chronic lower limb lymphedema (CL-LL) secondary to Kaposi sarcoma (KS) is not widely recognized as a cellulitis risk factor.
  • Kaposi sarcoma (KS) is an AIDS-defining malignancy that can cause significant morbidity.

Purpose of the Study:

  • To describe the clinical spectrum of cellulitis in patients with CL-LL due to KS.
  • To evaluate the use and effectiveness of antimicrobial prophylaxis in preventing cellulitis complications.

Main Methods:

  • Retrospective study of HIV patients with KS and CL-LL experiencing cellulitis at a Mexican cancer clinic (2004-2019).
  • Data collection included demographic, clinical factors, and outcomes such as hospitalization, recurrence, and mortality.

Main Results:

  • Thirty-nine male patients with CL-LL were analyzed. Key factors associated with cellulitis included lymph-node KS infiltration, fungal infections, and ulcerated lesions.
  • High rates of hospitalization (46.1%) and recurrence (35.8%) were observed. Mortality occurred in 25.3% of patients, including cases of toxic shock syndrome and septic shock.
  • Patients receiving antimicrobial prophylaxis (64.1%) experienced significantly fewer unfavorable outcomes (hospitalization, recurrence) compared to those without prophylaxis.

Conclusions:

  • CL-LL due to KS is a significant risk factor for cellulitis and severe complications, particularly in patients with prolonged life expectancy.
  • Antimicrobial prophylaxis demonstrates potential in preventing serious complications and should be further investigated in this patient population.
Abstract

Keywords:
AIDS-related Kaposi sarcomacellulitislower-limb lymphedemalymphedemapenicillin prophylaxis

More Related Videos

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

Published on: September 14, 2010

12.8K
Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients13:50

Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients

Published on: June 11, 2011

12.4K

Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
389
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.3K
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
44
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
73
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.7K
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
63