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[Cytology of body cavity fluids - established methods and new developments]

Marianne Engels1

  • 1Institut für Pathologie, Uniklinik Köln, Kerpener Str. 62, 50937, Köln, Deutschland. marianne.engels@uk-koeln.de.

Der Pathologe
|January 7, 2022
PubMed

Insights

Cytopathology of body cavity fluids is crucial. The International System for Serous Fluid Cytopathology (TIS) offers a standardized reporting system, improving diagnostic consistency and international recognition.

Area of Science:

  • Cytopathology
  • Fluid analysis
  • Diagnostic cytology

Background:

  • Body cavity fluids are frequently analyzed in cytology.
  • Cytomorphology is often supplemented with additive testing.
  • A new international terminology and classification system has been introduced.

Purpose of the Study:

  • To present cytopreparation and staining techniques.
  • To illustrate exemplary morphological patterns.
  • To introduce The International System for Serous Fluid Cytopathology (TIS).

Main Methods:

  • Discussion of technical issues in pleural effusion, pericardial effusion, and ascites.
  • Integration of immunocytochemistry and molecular diagnostics.
  • Analysis of reporting system variations.

Main Results:

  • Body cavity fluid analysis provides significant diagnostic information.
  • Additive testing is standard in routine practice.
  • Current reporting structures show considerable practical divergence.

Conclusions:

  • A universally applicable and recognized reporting system for serous fluid cytopathology is needed.
  • The International System for Serous Fluid Cytopathology (TIS) is a promising approach to standardization.
Abstract

Keywords:
Ascitic fluidsCytodiagnosisImmunohistochemistryMolecular pathologyTerminology

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