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Angioimmunoblastic T-cell lymphoma with exuberant plasmacytosis and spontaneous tumor lysis syndrome
Hafsa Faisal1, Syed Ather Hussain1, Rachel David2
1Department of Internal Medicine, Rochester General Hospital, Rochester, New York.
Insights
A 67-year-old man was diagnosed with angioimmunoblastic T-cell lymphoma after initial confusion with plasma cell leukemia. Prompt intervention for this rare lymphoma and its complications, like tumor lysis syndrome, is crucial for survival.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Angioimmunoblastic T-cell lymphoma (AITL) is an aggressive non-Hodgkin lymphoma.
- AITL often presents with constitutional symptoms and B symptoms.
Observation:
- A 67-year-old male presented with confusion, chills, night sweats, and poor oral intake.
- Initial laboratory findings revealed severe plasmacytosis, mimicking plasma cell leukemia.
Findings:
- Further investigations confirmed the diagnosis of angioimmunoblastic T-cell lymphoma.
- The patient experienced spontaneous tumor lysis syndrome during his hospital stay.
Implications:
- This case highlights the importance of comprehensive workup for accurate AITL diagnosis.
- Early recognition and management of AITL and its complications are critical for improving patient outcomes.
Abstract:
We present a 67-year-old man with complaints of confusion, chills, night sweats, and several days of poor oral intake. He had severe plasmacytosis on lab work, which initially raised concern for plasma cell leukemia. However, further workup led to the diagnosis of angioimmunoblastic T-cell lymphoma. His initial hospital course was complicated by spontaneous tumor lysis syndrome. Early recognition and prompt interventions are pivotal to improve survival outcomes in such patients.
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