Related Experiment Video

Updated: Aug 31, 2025

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

2.6K

An Atypical Case of Prolonged COVID-19 Infection

Connor Lewis1, Akash Gupta2, Neil K Gupta2

  • 1Internal Medicine, Yale School of Medicine, New Haven, USA.

Cureus
|August 19, 2022
PubMed

Insights

Immunocompromised patients with COVID-19 may experience prolonged illness. Cycle threshold values may not accurately reflect disease severity in these individuals, suggesting a need for better diagnostic tools and treatments.

Area of Science:

  • Infectious Diseases
  • Virology
  • Immunology

Background:

  • Immunocompromised individuals are at higher risk for severe and prolonged COVID-19.
  • Prolonged COVID-19 infections in this population can necessitate intensive care.
  • Non-Hodgkin's lymphoma survivors are a subset of immunocompromised patients.

Observation:

  • A 61-year-old immunocompromised female with a history of non-Hodgkin's lymphoma presented with a prolonged COVID-19 infection.
  • Despite clinical improvement, her cycle threshold (CT) values on RT-PCR tests continued to worsen.
  • This patient's course was compared to other reported cases in immunocompromised populations.

Findings:

  • Cycle threshold values may not reliably indicate disease severity or progression in immunocompromised COVID-19 patients.
  • RT-PCR assays targeting replicative viral RNA might offer better insights into severity and infectivity.
  • The patient's prolonged disease course mirrors patterns seen in other immunocompromised individuals.

Implications:

  • There is a critical need for enhanced treatment protocols for COVID-19 in immunocompromised patients.
  • Improved infection prevention strategies are essential for protecting this vulnerable population from SARS-CoV-2.
  • Further research into diagnostic markers for prolonged COVID-19 in immunocompromised individuals is warranted.

Keywords:
covid-19cycle thresholdimmunocompromisert pcrsars cov-2

More Related Videos

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

22.9K
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.3K

Related Concept Videos

Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
58.6K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
20
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
317
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
479
Immunological Memory01:23

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
3.7K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
449