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Updated: Aug 9, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Case report: Cellular therapy for hydroa vacciniforme-like lymphoproliferative disorder in pediatric common variable

Elżbieta Grześk1, Sylwia Kołtan1, Anna Dąbrowska1

  • 1Department of Pediatrics, Hematology and Oncology, Faculty of Medicine, Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Frontiers in Immunology
|August 22, 2022
PubMed

Insights

Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD), a severe Epstein-Barr virus (EBV) infection, poses risks for those with common variable immunodeficiency (CVID). This study details successful complex management using EBV-specific T cells and hematopoietic cell transplantation.

Area of Science:

  • Immunology
  • Oncology
  • Virology

Background:

  • Hydroa vacciniforme-like lymphoproliferative disorder (HV-LPD) is a rare, potentially aggressive Epstein-Barr virus (EBV) infection.
  • Patients with Inborn Errors of Immunity (IEI), like Common Variable Immunodeficiency (CVID), face heightened risks for severe viral infections and malignancies.
  • HV-LPD in IEI patients can progress to systemic lymphoma, necessitating advanced treatment strategies.

Keywords:
Allo-HCTCVID - common variable immunodeficiency disordersEBV-CTLsEBV-specific cytotoxic T cellsHV-LPDNGS - next generation sequencingallogeneic hematopoietic stem cell transplantation

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