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Research on the correlation of immunity in patients with chronic insomnia

Li Nie1, Xian-Li Pan1, Xiao-Bao Zhang1

  • 1Department of General Medicine, Chaohu Hospital Affiliated with Anhui Medical University, Chaohu, China.

Frontiers in Psychiatry
|November 4, 2022
PubMed

Insights

Chronic insomnia patients exhibit altered immunity and increased clinical infections. This study highlights immunological abnormalities in individuals with chronic insomnia, leading to a higher susceptibility to infections.

Area of Science:

  • Immunology
  • Sleep Medicine
  • Gerontology

Background:

  • Chronic insomnia is prevalent in older adults.
  • Immune system function can decline with age.
  • Understanding the interplay between chronic insomnia and immunity is crucial for public health.

Purpose of the Study:

  • To investigate immunological changes in patients with chronic insomnia.
  • To compare clinical infection rates between chronic insomnia patients and healthy controls.
  • To identify specific immune markers associated with chronic insomnia.

Main Methods:

  • Compared complete blood counts, biochemical indices, lymphocyte subsets, immunoglobulins, and interleukin-6 levels between 42 chronic insomnia patients and 47 controls.
  • Assessed differences in clinical infection incidence.
  • Analyzed erythrocyte, hemoglobin, hematocrit, albumin, globulin, creatinine, IgG, IgG/IgM ratio, CD4+ T-lymphocytes, CD19-lymphocytes, CD4+/CD8+ ratio, platelet/lymphocyte ratio, CD19/CD3 ratio.

Main Results:

  • Significant differences observed in erythrocyte, hemoglobin, hematocrit, albumin, globulin, creatinine, IgG, IgG/IgM ratio, CD4+ T-lymphocytes, CD19-lymphocytes, CD4+/CD8+ ratio, platelet/lymphocyte ratio, CD19/CD3 ratio, and clinical infection events (p < 0.05).
  • No significant differences in neutrophil, lymphocyte, monocyte, platelet counts, specific lymphocyte subsets (CD8+ T, CD56+), PLR, NLR, complement C3/C4, IgM, IgA, or IL-6 (p > 0.05).
  • Blood pressure did not significantly differ between groups (p > 0.05).

Conclusions:

  • Patients with chronic insomnia demonstrate immunological abnormalities.
  • Chronic insomnia is associated with a higher incidence of clinical infection.
  • These findings suggest a link between sleep disturbances and immune dysregulation.
Abstract

Keywords:
immunityimmunoglobulininfectioninsomnialymphocyte subsetsneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratio

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