Related Experiment Video

Updated: Aug 19, 2025

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

1.4K

Acute Anterior Uveitis with HLA-B27 Positivity after Corneal Cross-Linking with Previous Intrastromal Corneal Ring

Asher Khan1,2, Charles D McGuffey1, Andrew T Melson1

  • 1Dean McGee Eye Institute, 608 Stanton L. Young Blvd, Oklahoma City, OK 73104, USA.

Case Reports in Ophthalmological Medicine
|December 1, 2022
PubMed

Insights

Acute anterior uveitis (AAU) occurred after corneal cross-linking (CXL) in a patient with keratoconus. HLA-B27 positivity was identified, highlighting the need for systemic evaluation post-CXL.

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Immunology

Background:

  • Keratoconus (KCN) management often involves intrastromal corneal ring segments.
  • Epithelium-off corneal cross-linking (CXL) is a standard treatment for progressive KCN.
  • Acute anterior uveitis (AAU) is a potential complication following ocular procedures.

Observation:

  • A 28-year-old male with KCN and prior intrastromal corneal ring segments underwent CXL.
  • Postoperatively, the patient developed symptoms of AAU, including pain, redness, hypopyon, and decreased visual acuity.
  • Treatment with topical antibiotics, steroids, and oral antivirals led to clinical improvement and visual recovery.

Findings:

  • Diagnostic workup revealed the patient was positive for HLA-B27.
  • This finding suggests a potential association between HLA-B27 and post-CXL AAU in this patient profile.
  • The patient's demographic profile showed overlap with common KCN and HLA-B27 positive populations.

Implications:

  • Comprehensive laboratory workup is crucial for identifying systemic associations in AAU post-CXL.
  • Clinicians should consider HLA-B27 associated uveitis in the differential diagnosis for patients presenting with AAU after CXL, especially those with KCN.
  • Early identification and management of associated systemic conditions can optimize patient outcomes.

More Related Videos

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

20.0K
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis10:33

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

2.8K

Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
613
Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
685
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
520