Related Experiment Video

Updated: Aug 17, 2025

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
08:56

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

2.8K

Characteristic cerebrospinal fluid findings in immune checkpoint inhibitor-related peripheral neuropathy: A case

Sho Wako1, Ryotaro Ikeguchi1, Kunio Toda1

  • 1Department of Neurology, Tokyo Women's Medical University, Tokyo, Japan.

Journal of Neuroimmunology
|December 12, 2022
PubMed

Insights

Immune checkpoint inhibitors (ICIs) can cause peripheral neuropathy. Cerebrospinal fluid analysis revealed elevated cytokines and soluble interleukin-2 receptor, suggesting T cell autoimmunity and potential biomarkers for diagnosis.

Area of Science:

  • Neuroimmunology
  • Oncology
  • Biomarker Discovery

Background:

  • Immune checkpoint inhibitors (ICIs) are crucial for treating unresectable tumors.
  • Immune-related adverse events (irAEs), including neurological toxicities, are known side effects of ICIs.
  • Peripheral neuropathy is a significant neurological irAE.

Observation:

  • A case of ICI-related peripheral neuropathy (irPN) presented with specific cerebrospinal fluid (CSF) abnormalities.
  • CSF analysis revealed not only pleocytosis and elevated protein levels but also increased concentrations of soluble interleukin-2 receptor (sIL-2R), IL-6, and IL-10.
  • These CSF findings suggest an underlying T cell-mediated autoimmune process.

Findings:

  • The study identified elevated CSF sIL-2R, IL-6, and IL-10 levels in a patient with irPN.
  • These elevated cytokines and sIL-2R indicate a role for activated T cells in the pathogenesis of irPN.
  • The findings highlight a potential link between specific CSF cytokine profiles and ICI-induced neuropathy.

Implications:

  • CSF sIL-2R, IL-6, and IL-10 may serve as novel biomarkers for diagnosing irPN.
  • Identifying these biomarkers could lead to earlier diagnosis and more targeted management of ICI-related neurological toxicities.
  • This research contributes to understanding the mechanisms of neurotoxicity associated with immunotherapy.

Keywords:
BiomarkerCerebrospinal fluidImmune checkpoint inhibitorImmune-related adverse eventMelanomaPeripheral neuropathy

More Related Videos

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

12.4K
Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis09:01

Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis

Published on: November 17, 2020

7.2K

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
24