Related Experiment Video

Updated: Aug 12, 2025

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

5.8K

The role of CD74 in cardiovascular disease

Qiu-Lin Li1,2, Jing Tang1,2,3, Ling Zhao1,2

  • 1State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asian, Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, China.

Frontiers in Cardiovascular Medicine
|January 30, 2023
PubMed

Insights

Leukocyte differentiation antigen 74 (CD74) is crucial in cardiovascular disease, acting as a receptor for MIF proteins and influencing antigen presentation. This review explores CD74

Area of Science:

  • Immunology and Molecular Biology
  • Cardiovascular Research

Background:

  • Leukocyte differentiation antigen 74 (CD74), or invariant chain, is a key molecular chaperone for MHC class II molecules.
  • CD74 functions as a receptor for macrophage migration inhibitory factor (MIF) family proteins.
  • Emerging evidence highlights CD74's significant role in the pathogenesis of cardiovascular diseases.

Purpose of the Study:

  • To systematically review the structure and functions of CD74.
  • To summarize recent research on CD74's involvement in cardiovascular diseases.
  • To discuss potential CD74-targeting therapeutic strategies.

Main Methods:

  • Systematic literature review.
  • Analysis of existing research on CD74 structure, function, and disease association.
  • Synthesis of data on CD74's role in cardiovascular pathology and therapeutic potential.

Main Results:

  • CD74's dual role as an MHC II chaperone and MIF receptor is detailed.
  • Significant associations between CD74 and various cardiovascular conditions are identified.
  • Potential therapeutic avenues targeting CD74 in cardiovascular disease are outlined.

Conclusions:

  • CD74 is a critical mediator in cardiovascular disease.
  • Targeting CD74 presents a promising therapeutic strategy.
  • This review addresses knowledge gaps concerning CD74 in cardiovascular pathology.

Keywords:
CD74D-DT/MIF2MIFcardiovascular diseasesinvariant chain

More Related Videos

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly06:09

Using En Face Immunofluorescence Staining to Observe Vascular Endothelial Cells Directly

Published on: August 20, 2019

15.5K
Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization08:13

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

4.7K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
44
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
30
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
22
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
1.4K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
25
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
16