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Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
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Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

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Current Knowledge of Th22 Cell and IL-22 Functions in Infectious Diseases

Kunyu Zhang1,2,3,4, Lei Chen1,2,3, Chenyu Zhu1,2,3,4

  • 1Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

Pathogens (Basel, Switzerland)
|February 25, 2023
PubMed

Insights

T helper 22 (Th22) cells, crucial CD4+ T-cells, produce IL-13, IL-22, and TNF-α. Th22/IL-22 show dual roles in immunity, offering protection against some infections but worsening others, suggesting therapeutic potential.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • T helper 22 (Th22) cells are a distinct CD4+ T-cell lineage.
  • They secrete key cytokines including IL-13, IL-22, and TNF-α.
  • Th22 cells express chemokine receptors like CCR4, CCR6, and CCR10.

Purpose of the Study:

  • To review the current understanding of Th22 cells.
  • To explore their differentiation and mechanisms.
  • To analyze the impact of Th22/IL-22 on human infectious diseases.

Main Methods:

  • Literature review of studies on Th22 cells and IL-22.
  • Analysis of cytokine profiles and chemokine receptor expression.
  • Examination of the dual roles of Th22/IL-22 in various infections.

Main Results:

  • Th22 cells and their primary effector molecule, IL-22, exhibit variable roles in human immunity.
  • IL-22, acting via IL-22R, influences downstream signaling pathways.
  • Protective anti-inflammatory effects were observed against HIV and influenza.
  • Pro-inflammatory activities were noted to exacerbate hepatitis B and Helicobacter pylori infections.

Conclusions:

  • Th22/IL-22 present a dual role in infectious diseases, acting as both protective and detrimental.
  • Understanding Th22 cell mechanisms is crucial for therapeutic development.
  • Th22/IL-22 may represent a promising therapeutic target for managing various infections.

Keywords:
IL-22Th22 cellsimmunityinfection

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