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EBV-positive diffuse large B-cell lymphoma presenting as symptomatic masses in the bladder trigone and unilateral

Samuel K Luketich1, David S Zekan2, Ion Prisneac3

  • 1West Virginia University School of Medicine, Morgantown, WV, 26505, USA.

Urology Case Reports
|March 3, 2023
PubMed

Insights

This case report details a rare instance of Epstein-Barr Virus positive Diffuse Large B-cell Lymphoma (DLBCL) affecting the genitourinary tract in a patient with a history of multiple myeloma and prostate cancer.

Area of Science:

  • Oncology
  • Uro-oncology
  • Hematology

Background:

  • Diffuse Large B-cell Lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
  • Genitourinary tract involvement by DLBCL is exceptionally rare.
  • Co-occurrence with prior malignancies like multiple myeloma and prostate cancer presents diagnostic challenges.

Observation:

  • A 66-year-old male presented with gross hematuria and urinary clot retention.
  • Incidental renal and bladder masses were detected via imaging.
  • Biopsy confirmed Epstein-Barr Virus (EBV) positive DLBCL in both locations.

Findings:

  • The patient was diagnosed with Stage IV DLBCL, evidenced by significant lymphadenopathy.
  • The lymphoma was positive for Epstein-Barr Virus (EBV).
  • The patient had a history of multiple myeloma and prostate cancer.

Implications:

  • This case highlights the importance of considering rare diagnoses in patients with complex medical histories.
  • Early detection and multidisciplinary management are crucial for improving outcomes in genitourinary DLBCL.
  • Further research into EBV-positive DLBCL in the genitourinary tract may elucidate specific treatment strategies.

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