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Pleurisy as a Sign of Chronic Lymphocytic Leukemia

Afaf Thouil1, Mohamed Lakhal1, Houda Bachir2

  • 1Department of Respiratory Diseases, Laboratory of Research and Medical Sciences, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, MAR.

Cureus
|May 1, 2023
PubMed

Insights

Diagnosing chronic lymphoid leukemia (CLL) typically involves blood tests. This case highlights CLL secondary localization in pleural effusion, confirmed by biopsy and immunohistochemistry, requiring chemotherapy.

Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Chronic lymphoid leukemia (CLL) diagnosis relies on peripheral blood analysis.
  • Extranodal or unusual disease presentations can occur in CLL.
  • Pleurisy is an uncommon manifestation of CLL.

Observation:

  • A patient presented with pleurisy, characterized by lymphocytic exudate.
  • Pleural effusion analysis revealed atypical lymphocytes.
  • Histological examination of pleural biopsy was crucial.

Findings:

  • Immunohistochemistry confirmed secondary localization of CLL in the pleura.
  • Diagnosis of CLL was established through pleural fluid and tissue analysis.
  • The patient's condition was identified as a rare manifestation of CLL.

Implications:

  • This case underscores the importance of considering unusual disease sites in CLL diagnosis.
  • Diagnostic strategies for CLL may need to include tissue biopsy in specific cases.
  • Early identification of secondary CLL localization is vital for effective treatment initiation.

Keywords:
chemotherapyleukemic effusionmalignant blood diseasespleurisythe diagnosis of lymphoid leukemia (cll)

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