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Hippocampal area CA2: interneuron disfunction during pathological states

Rebecca A Piskorowski1,2, Vivien Chevaleyre1,2

  • 1Université Paris Cité, INSERM UMRS 1266, Institute of Psychiatry and Neuroscience of Paris, GHU Paris Psychiatrie et Neurosciences, Paris, France.

Frontiers in Neural Circuits
|May 14, 2023
PubMed

Insights

Area CA2 is crucial for social memory and shows unique inhibitory plasticity. Alterations in CA2

Area of Science:

  • Neuroscience
  • Synaptic Plasticity
  • Hippocampal Function

Background:

  • Hippocampal area CA2 is vital for social recognition memory.
  • Area CA2 possesses distinct cellular and molecular characteristics.
  • Unique inhibitory transmission and plasticity observed in area CA2.

Purpose of the Study:

  • To review recent findings on area CA2 alterations in neurological and psychiatric disorders.
  • To explore changes in inhibitory transmission and plasticity in area CA2.
  • To correlate these changes with social cognition deficits in various pathologies.

Main Methods:

  • Review of recent studies utilizing mouse models.
  • Analysis of research on multiple sclerosis, autism spectrum disorder, Alzheimer's disease, schizophrenia, and 22q11.2 deletion syndrome.
  • Focus on inhibitory transmission and synaptic plasticity in area CA2.

Main Results:

  • Changes in inhibitory transmission and plasticity of area CA2 are evident in multiple disease models.
  • These alterations are consistently observed across diverse neurological and psychiatric conditions.
  • Specific deficits in social cognition are linked to these CA2 synaptic changes.

Conclusions:

  • Area CA2's unique inhibitory system is implicated in social cognition deficits.
  • Dysregulation of CA2 inhibitory transmission and plasticity is a common feature across several pathologies.
  • Targeting area CA2 may offer therapeutic potential for social cognitive impairments.

Keywords:
22q11.2DSAlzheimer’s diseaseautism spectrum disorderepilepsyhippocampal area CA2inhibitory transmissionmultiple sclerosisschizophrenia

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